Heinz Ludwig, MD, Wilhelminen Cancer Research Institute, Wilhelminenspital, Vienna, Austria, comments on the results of the Phase III DETERMINATION study (NCT01208662) evaluating the use of lenalidomide, bortezomib, and dexamethasone (RVD) versus high-dose melphalan-based conditioning with autologous hematopoietic stem cell transplantation (autoHSCT) in patients with newly diagnosed multiple myeloma (NDMM), discussing progression-free survival (PFS) and overall survival (OS), and the implications of these findings in clinical decision-making. This interview took place at the European Hematology Association (EHA) Congress 2022 held in Vienna, Austria.