Matthew Davids, MD, Dana-Farber Cancer Institute, Boston, MA, discusses the single-arm, multi-center, Phase II trial (NCT02251548) of ibrutinib plus fludarabine, cyclophosphamide, and rituximab (iFCR) as an initial treatment for younger patients with chronic lymphocytic leukemia (CLL). This interview took place at the 15th International Conference on Malignant Lymphoma (ICML), in Lugano, Switzerland.