The management of chronic lymphocytic leukemia (CLL) has progressed dramatically, moving into an era of tailored treatment. Here, Alessandra Tedeschi, MD, PhD, of the Niguarda Cancer Center, Milan, Italy, speaking from the European Research Initiative on CLL (ERIC) International Meeting 2018, held in Barcelona, Spain, discusses the tailoring of CLL treatment using a variety of predictive factors, including 17p deletion and IGHV mutation. Dr Tedeschi also adresses a number of current concerns, such as the limited number of salvage therapy options in this space.