At the Controversies in Multiple Myeloma (COMy) 2019 World Congress in Paris, France, Inger Nijhof, MD, PhD, of VU University Medical Center, Amsterdam, Netherlands, discusses the need for clinical trials that compare treatments with and without autologous stem cell transplantation (auto-SCT). Dr Nijhof highlights that auto-SCT is performed due to concerns surrounding the risks of not carrying it out.