In this video, Graham Collins, MA, MBBS, MRCP, FRCPath, DPhil, Oxford University Hospitals NHS Foundation Trust, Oxford, UK, discusses the HD21 trial (NCT02661503), a highly anticipated clinical trial comparing the use of escalated BEACOPP with BrECADD in patients with classical Hodgkin lymphoma (HL). Dr Collins first discusses the differences between the BEACOPP and BrECADD protocols, and further explains the main aim of this study, which is to investigate whether BrECADD is less toxic than the commonly used escalated BEACOPP approach. This interview took place at the 62nd Annual Scientific Meeting of the British Society for Haematology (BSH) 2022, in Manchester, UK.