Claudio Cerchione, MD, PhD, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy, talks on the use of measurable residual disease (MRD) to measure the depth of response to therapy for patients with multiple myeloma, and its potential to guide treatment. Dr Cerchione talks on the need for MRD-negativity to become integrated into daily clinical practice. This interview took place during the 18th International Myeloma Workshop (IMW 2021) congress.