ASCO 2022 | The rationale behind targeting ROR1 in CLL and MCL
Parag Jasani, MBBS, MRCP, FRCPath, FRCP, University College Hospital, London, UK, talks on the rationale behind the first-in-human Phase I study (NCT04763083) investigating a bispecific T-cell engager, NVG-111, which targets CD3 and ROR1, in patients with relapse-refractory chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL). ROR1 is expressed in both hematological and solid cancers and is not usually expressed on normal tissue, thereby significantly reducing the risk of off-target side effects. Many solid and hematological cancers possess cancer-initiating stem cells on which ROR1 is expressed, thus, targeting ROR1 may hold the potential of broadening its use to multiple malignancies. This interview took place at the American Society of Clinical Oncology (ASCO) 2022 Annual Meeting in Chicago, IL.
