David Miklos, BSc, MD, PhD, Stanford University, Stanford, CA, talks on the ongoing challenges of axicabtagene ciloleucel (axi-cel) in patients with large B-cell lymphomas, commenting on the impact of financial support, and the importance of communicating the benefits of axi-cel therapy to healthcare professionals and patients. Prof. Miklos also discusses the future use of axi-cel in other lymphomas and acute lymphoblastic leukemia, and discusses future directions for chimeric antigen receptor T-cell (CAR-T) therapies, with the potential development of dual-targeting CARs and allogeneic CAR-T therapies. This interview took place at the virtual European Hematology Association (EHA) Congress 2021.