Farhad Ravandi, MD, University of Texas MD Anderson Cancer Center, Houston, TX, comments on the safety and efficacy of nelarabine, pegylated asparaginase, and venetoclax in the frontline treatment of T-cell acute lymphoblastic leukemia (T-ALL). Dr Ravandi explains that the combination of nelarabine and pegylated asparaginase is well tolerated, but venetoclax can only be added for 1-2 cycles as it is myelosuppressive. This interview took place at the European Hematology Association (EHA) Congress 2022 held in Vienna, Austria.