Jacqueline Garcia, MD, Dana-Farber Cancer Institute, Boston, MA, discusses the current landscape of treatment for higher-risk myelodysplastic syndromes (HR-MDS). Although transplantation is the gold standard, eligibility is limited for most patients. Ongoing clinical trials explore combinations of hypomethylating agents (HMAs), immunotherapies, small molecule inhibitors, and targeted therapies with the aim of enhancing survival outcomes and delaying progression to acute myeloid leukemia (AML). This interview took place at the 65th ASH Annual Meeting and Exposition, held in San Diego, CA.
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