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iwMDS/iwMPN 2026 | Does CAR T-cell therapy have a future in MDS?

Mohamed Kharfan Dabaja, MD, MBA, FACP, Mayo Clinic, Jacksonville, FL, discusses the potential role of non-transplant cellular therapies in myelodysplastic syndromes (MDS). Dr Kharfan Dabaja highlights emerging CAR T-cell therapies targeting CLL-1 and LILRB4 in myeloid malignancies, exploring challenges related to target selection, immunosuppression, and the potential role of CAR-T as a bridge to allogeneic stem cell transplantation. This presentation took place at the 4th International Workshop on Myelodysplastic Syndromes & Myeloproliferative Neoplasms (iwMDS/iwMPN) 2026, held in Washington, DC.

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