Pieter Sonneveld, MD, PhD, Erasmus Medical Center Cancer Institute, Rotterdam, The Netherlands, highlights the key points from his presentation at COMy 2022 on how to approach patients with high-risk cytogenetics in multiple myeloma. Prof. Sonneveld notes some of the challenges including the multiple definitions used to define high-risk disease, as well as lower numbers of patients included in clinical trials. In this video, Prof. Sonneveld describes the suggestions he made at the COMy 2022 meeting to address these issues. This interview took place at the 8th World Congress on Controversies in Multiple Myeloma (COMy) 2022, held in Paris, France.