In this video, Morie Gertz, MD, MACP, Mayo Clinic College of Medicine, Rochester, MN, discusses research showing that the presence of a measurable monoclonal spike (M-spike) before autologous stem cell transplantation (ASCT) is associated with shorter survival in patients with light chain (AL) amyloidosis. This interview took place during the 62nd American Society of Hematology (ASH) Annual Meeting and Exposition, 2020.