Daniele Derudas, MD, Businco Hospital, Cagliari, Italy, discusses the management of unfit/frail multiple myeloma patients in Italy, including defining fraility and fitness status in the disease population and using the appropriate therapies in these multiple myeloma patients, including low dosages or using agents with reduced toxicities in order to maintain quality of life. This interview was recorded via an online conference call with The Video Journal of Hematological Oncology (VJHemOnc).