Andrew Wei, MBBS, PhD, of Alfred Hospital and Monash University, Melbourne, Australia, discusses the latest research from his institute in the area of targeting apoptosis for the treatment of acute myeloid leukemia (AML). Dr Wei highlights the combinantion of BCL-2 and MCL-1 inhibitors, which have shown potent activity in pre-clinical models and are now moving into trials. This interview took place at the International Symposium on Acute Leukemias (ISAL) 2019, held in Munich, Germany.