In this video, Santosh Saraf, MD, University of Illinois Hospital, Chicago, IL, briefly discusses strategies to manage kidney disease in patients with sickle cell disease (SCD). Dr Saraf first discusses current and emerging agents, including hydroxyurea, ACE inhibitors, and voxelotor, and further highlights the need for more targeted therapies. This interview took place at the European Hematology Association (EHA) Congress 2022 held in Vienna, Austria.