Undetectable measurable residual disease (uMRD) with venetoclax therapy is associated with improved PFS in patients with chronic lymphocytic leukemia (CLL). Chaitra Ujjani, MD, University of Washington & Fred Hutchinson Cancer Research Center, Seattle, WA, explains the rationale of utilizing MRD assessment with a next generation sequencing (NGS) assay in order to guide clinical decision making in patients with CLL that are receiving venetoclax-based regimens. This interview took place at the American Society of Hematology (ASH) 2019 Annual Meeting and Exposition in Orlando, FL.