In this interview at the Controversies in Multiple Myeloma (COMy) 2019 World Congress in Paris, France, Mohamad Mohty, MD, PhD of Saint-Antoine Hospital, Paris, France, discusses some of the highlights from the 5th COMy Congress, which had a record number of participants. Prof. Mohty discusses the movement towards a focus on targeting the microenvironment to synergize with drugs, investigating resistance mechanisms and further enhancing drug efficacy.