ASH 2021 | The impact of CHIP in Alzheimer’s disease risk

Name: The impact of CHIP in Alzheimer’s disease risk
Uploaded: 2021-12-12T00:00:00Z
Duration: 2 min 2 s

Siddhartha Jaiswal • 12 Dec 2021

ASH 2021

General

Clonal hematopoiesis of indeterminate potential (CHIP) is a precursor state for many blood cancers and it has also been associated with chronic inflammatory diseases of aging. In this video, Siddhartha Jaiswal, MD, PhD, Stanford University, Stanford, CA, comments on the results of a study investigating the association between CHIP and Alzheimer’s disease (AD). The study found that CHIP was correlated with a reduced risk of AD. In addition, it was shown that seven out of eight CHIP carriers had evidence of mutations in their microglial pool, and further analysis in two of these carriers showed that 40-80% of microglia had been replaced by mutated precursors, which may provide a protective effect in AD. This interview took place at the 63rd ASH Annual Meeting and Exposition congress in Atlanta, GA.