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SOHO 2022 | Mechanisms of resistance to venetoclax in AML and methods being explored to overcome these

In this video, Marina Konopleva, MD, PhD, Albert Einstein College of Medicine, New York, NY, discusses mechanisms of resistance to venetoclax in patients with acute myeloid leukemia (AML) and methods being investigated to overcome these. Prof. Konopleva first explains two major mechanisms that have been shown to cause venetoclax resistance, including mutations in signaling pathways and mutations in the TP53 gene, and then goes on to discuss clinical trials evaluating combination approaches to overcome these mechanisms of resistance. This interview took place at the Tenth Annual Meeting of the Society of Hematologic Oncology (SOHO) held in Houston, TX.

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