ASH 2023 | Real-world outcomes of patients with BV and anti-PD-1 intolerant cHL: the impact of alloSCT & CAR-T
Timothy Voorhees, MD, MSCR, The Ohio State University Wexner Medical Center, Columbus, OH, shares the findings of a retrospective real-world analysis of data from 14 academic centers in the United States which investigated the long-term outcomes of patients with classical Hodgkin lymphoma (cHL) who were refractory or intolerant to brentuximab vedotin (BV) and anti-PD-1 therapy. Patients who received allogeneic stem cell transplantation (alloSCT) or CD30-directed CAR T-cell therapy had a longer overall survival (OS) than those not receiving these therapies. Dr Voorhees also reveals that rechallenging with BV or anti-PD-1 elicited a high overall response rate (ORR); however, median progression-free survival (PFS) was less than a year, and therefore, rechallenge may be considered as a bridging option in patients. This interview took place at the 65th ASH Annual Meeting and Exposition, held in San Diego, CA.
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Disclosures
Consultancy: Novartis, Recordati; Research Funding: Recordati, AstraZeneca, Incyte, Morphosys.
