Stefano Luminari, MD, University of Modena and Reggio Emilia, Emilia-Romagna, Italy, summarizes the results of the Phase III FOLL12 trial (NCT02063685) assessing response adapted maintenance in patients with follicular lymphoma. All patients received induction immunochemotherapy and patients in the standard arm received rituximab, whereas patients in the experimental arm received differing treatments depending on their metabolic and molecular response. Patients receiving response adapted maintenance had inferior responses in terms of progression-free survival. This interview took place during the 2021 International Conference on Malignant Lymphoma (16-ICML).