Michele Cavo, MD, from the Bologna University School of Medicine, Bologna, Italy, discusses current guidelines for induction therapy for autologous stem cell transplantation at the 2017 World Congress on Controversies in Multiple Myeloma (COMy) in Paris, France. The International Myeloma Working Group and the ESMO guidelines recommend a three-drug regimen including a proteasome inhibitor as the standard of care induction therapy for patients undergoing autologous stem cell transplantation. Lenalidomide is recommended as the standard of care maintenance therapy for this treatment.