Nina Shah, MD, of the University of California, San Francisco, CA, talks on the optimal time to initiate therapy for newly diagnosed multiple myeloma (NDMM), and how the induction therapy landscape is evolving. Dr Shah outlines the key trials studying combination treatment with three or more agents such as the GRIFFIN trial (NCT02874742) investigating daratumumab, lenalidomide, bortezomib, and dexamethasone versus lenalidomide, bortezomib, and dexamethasone for NDMM. This interview took place during the ninth annual meeting of the Society of Hematologic Oncology (SOHO 2021) congress.