Miguel Gallardo, PhD, Spanish National Cancer Research Center (CNIO), Madrid, Spain, discusses the impact of RNA binding proteins (RBPs) in the development and progression of various hematological malignancies. Dr Gallardo first highlights how the over-expression of RBPs, including hnRNP K, can promote hematopoietic stem cell exhaustion and bone marrow failure, and then goes on to discuss some ongoing research in the field. This interview took place at the European Hematology Association (EHA) Congress 2022 held in Vienna, Austria.