BSH 2019 | APL-2: mechanism of action within the complement system

Bruno Fattizzo

APL-2 binds to C3 and blocks the cleavage of C3 into C3a and C3b by C3 convertase. Bruno Fattizzo, MD, of the University of Milan, Milan, Italy, discusses the mechanism of action of APL-2 within the complement system and how this impacts hemolysis and hemoglobin levels at the British Society for Haematology (BSH) 2019 Annual Meeting, held in Glasgow, UK.

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