Elena Zamagni, MD, PhD, University of Bologna, Bologna, Italy, briefly discusses the key limitations of current risk stratification tools for smoldering multiple myeloma (SMM) and monoclonal gammopathy of undetermined significance (MGUS). The existing tools are static, focusing only on clinical factors without accounting for the dynamic progression of the disease, and lack a comprehensive biological perspective. Several groups are actively seeking to incorporate and understand these missing features. This interview took place at the 21st International Myeloma Society (IMS) Annual Meeting, held in Rio de Janeiro, Brazil.
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