Matthew Davids, MD, Dana-Farber Cancer Institute, Boston, MA, briefly discusses the role of next-generation Bruton’s tyrosine kinase (BTK) inhibitors, including acalabrutinib, zanubrutinib, and pirtobrutinib, in the treatment of chronic lymphocytic leukemia (CLL). This interview took place at the European Hematology Association (EHA) Congress 2022 held in Vienna, Austria.