Jessica Okosun, MA, MB BChir, MRCP, FRCPath, PhD, of the Barts Cancer Institute, London, UK, gives an overview of the molecular pathogenesis of follicular lymphoma, and its relevance in clinical practice. Dr Okosun also talks on patient heterogeneity and on how predictive biomarkers enable the categorization of patients into high- and low-risk categories, and can be used to guide treatment. A gene expression model based on the PRIMA trial (NCT00140582) looked at 23 genes to predict progression free survival (PFS) rates. This interview took place during the ninth annual meeting of the Society of Hematologic Oncology (SOHO 2021) congress.