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IMS 2022 | Epigenetic dysregulation in ASXL-1-mutant CMML

Moritz Binder, MD, MPH, Mayo Clinic, Rochester, MN, comments on epigenetic dysregulation and oncogenic gene expression in ASXL-1-mutant chronic myelomonocytic leukemia (CMML), commenting on the results of a study that demonstrated de novo accessibility of high-risk oncogenic enhancer elements in ASXL-1-mutant CMML, and highlighting the possibility of targeting transcription factors that bind to these enhancers. This interview took place at the 19th International Myeloma Society Meeting (IMS) held in Los Angeles, CA.

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