Marina Konopleva, MD, PhD, The University of Texas MD Anderson Cancer Center, Houston, TX, discusses Ph-like acute lymphoblastic leukemia (ALL), a poor responding subset of ALL, that shares similar genetic abnormalities as Ph-positive chronic lymphocytic leukemia, without t[9;22]. This interview was recorded via an online conference call with The Video Journal of Hematological Oncology (VJHemOnc).