Naresh Bumma, MD, The Ohio State University Comprehensive Cancer Center, Columbus, OH, describes the mechanism of action (MOA) of REGN5458, a BCMAxCD3 bispecific antibody, and outlines challenges and remaining questions in the field of BCMA-directed therapies, including managing failure to BCMA-directed therapies, and choosing between different BCMA-directed agents. This interview took place at the 64th ASH Annual Meeting and Exposition congress in New Orleans, LA.
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