Andrew Kuykendall, MD, H. Lee Moffitt Cancer Center, Tampa, FL, discusses clinical risk factors for progression in myeloproliferative neoplasms (MPNs). Dr Kuykendall first highlights two key progression events that occur in patients with MPNs: progression from essential thrombocythemia (ET) or polycythemia vera (PV) to myelofibrosis (MF), and progression from ET, PV, or MF to acute leukemia. Dr Kuykendall then highlights cytogenetic factors that play a role in disease progression. This interview took place at the third annual Texas MPN Workshop (TMW) 2022, held in San Antonio, TX.