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ASH 2023 | Pelabresib plus ruxolitinib for the treatment of intermediate- and high-risk myelofibrosis

John Mascarenhas, MD, Icahn School of Medicine at Mount Sinai, New York, NY, summarizes the findings of the randomized, double-blind Phase III MANIFEST-2 study (NCT04603495). The trial compared the bromodomain and extra terminal (BET) protein inhibitor pelabresib plus ruxolitinib to ruxolitinib plus placebo in patients with treatment-naïve myelofibrosis (MF). Results of the trial were positive in both intermediate- and high-risk patients. This interview took place at the 65th ASH Annual Meeting and Exposition, held in San Diego, CA.

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Membership on an entity’s Board of Directors or advisory committees: Bristol Myers Squibb, Celgene, Constellation Pharmaceuticals/MorphoSys, CTI BioPharma, Galecto, Geron, GSK, Incyte Corporation, Karyopharm Therapeutics, Novartis, PharmaEssentia, Prelude Therapeutics, Pfizer, Merck, Roche, AbbVie, Kartos; Research Funding: AbbVie, Bristol Myers Squibb, Celgene, Constellation Pharmac, CTI BioPharma, Geron, Incyte Corporation, Novartis, Janssen, Kartos Therapeutics, Merck, PharmaEssentia, Roche;  Consultancy: Incyte, Novartis, Roche, Geron, GSK, Celgene/BMS, Kartos, AbbVie, Karyopharm, PharmaEssentia, Galecto, Imago, Sierra Oncology, Pfizer, MorphoSys, CTI Bio, AbbVie, Merck; Honoraria: GSK.