John Mascarenhas, MD, Icahn School of Medicine at Mount Sinai, New York, NY, summarizes the findings of the randomized, double-blind Phase III MANIFEST-2 study (NCT04603495). The trial compared the bromodomain and extra terminal (BET) protein inhibitor pelabresib plus ruxolitinib to ruxolitinib plus placebo in patients with treatment-naïve myelofibrosis (MF). Results of the trial were positive in both intermediate- and high-risk patients. This interview took place at the 65th ASH Annual Meeting and Exposition, held in San Diego, CA.
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