Acute lymphoblastic leukemia (ALL) is a malignant disorder of lymphoid progenitor cells affecting both adults and children. With a greater understanding of the disease and treatment approaches, there can be better outcomes for patients. In this podcast, Carolina Vincente-Duenas from the Institute of Biomedical Research, Salamanca, Spain, Talha Badar of the Medical College of Wisconsin, Milwaukee, WI, and Christina Peters of St. Anna Children’s Hospital, Vienna, Austria, discuss key updates in ALL presented at this year’s virtual European Hematology Association (EHA) 2020 congress.