Advances in both the treatment landscape and the pathology of the disease have improved the outcome of children and adults with acute lymphoblastic leukemia (ALL). However, many challenges still remain, including the treatment of older patients with ALL, diagnosis of Philadelphia chromosome-like (Ph-like) ALL, a newly identified aggressive subtype, as well as the evolving role of hematopoietic stem cell transplantation.

In this exclusive podcast, VJHemOnc spoke with Selina Luger, MD, of the University of Pennsylvania, Philadelphia, PA, Sarah Tasian, MD, from The Children’s Hospital of Philadelphia, Philadelphia, PA and David Marks, MBBS, PhD, FRACP, FRCPath, of the University Hospitals Bristol NHS Foundation Trust, Bristol, UK, who discuss the challenges in managing older patients with ALL, diagnostic testing modalities for Ph-like ALL and post-allogeneic stem cell transplantation interventions to prevent and treat relapse in patients.