Here, Peter Valk, PhD, from the Erasmus University Medical Center, Rotterdam, Netherlands, discusses The HARMONY Alliance, specifically the results from the Proof-of-Principle study for acute myeloid leukemia (AML). The study used large datasets to analyze various indications for clinically relevant information such as mutation prevalence. This interview took place at the 24th Congress of the European Hematology Association (EHA) 2019, held in Amsterdam, Netherlands.