In this interview, Noopur Raje, MD, of Massachusetts General Hospital, Boston, MA, discusses the Phase III MAIA study (NCT02252172) that aims to further establish the role of daratumumab in the treatment of transplant-ineligible newly diagnosed multiple myeloma (NDMM). Dr Raje also discusses her views on the TOURMALINE-MM3 trial (NCT02181413), showing that maintenance therapy with ixazomib, an oral proteasome inhibitor, was found to significantly prolong progression-free survival following autologous stem cell transplantation in NDMM.