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Proposed updates to AML classification: implications for clinical trials and practice

Robert Hasserjian, MD, Massachusetts General Hospital, Boston, MA, presents proposed updates to the classification of acute myeloid leukemia (AML) from the Classification Advancements Meeting (CAM) and discusses the implications for diagnosis and treatment. Dr Hasserjian recommends that all cases of AML undergo comprehensive genetic testing and be classified according to a defined hierarchy. He discusses key categories, including AML with recurrent genetic abnormalities, AML with mutated TP53, myelodysplasia-related AML defined by mutations or cytogenetic abnormalities, and AML defined by differentiation. This presentation took place at the 8th International Workshop on Acute Leukemias (iwAL) in Cambridge, MA.

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