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ASH 2025 | Evaluation of suspected Richter’s transformation during long-term BTK inhibitor therapy

Paul Hampel, MD, Mayo Clinic, Rochester, MN, discusses the evaluation of suspected Richter’s transformation in patients receiving long-term BTK inhibitor therapy. He highlights PET-CT as the primary diagnostic tool and emphasizes early imaging and biopsy when clinical or radiographic features raise concern. This interview took place at the 67th ASH Annual Meeting and Exposition, held in Orlando, FL.

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