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ASH 2025 | Decoding DDX41: clinical impact of germline and somatic mutations in high-risk myeloid neoplasms

Talha Badar, MD, Mayo Clinic, Rochester, MN, reviews outcomes in patients with high-risk myeloid neoplasms harboring DDX41 mutations. Dr Badar highlights that while these patients often have favorable survival, responses to venetoclax-based therapy vary, and co-occurring mutations may drive resistance. This interview took place at the 67th ASH Annual Meeting and Exposition, held in Orlando, FL.

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