Marina Konopleva, MD, PhD, Albert Einstein College of Medicine, New York City, NY, provides insights into the molecular mechanisms underlying the potential efficacy of pivekimab sunirine, a CD123-targeting antibody-drug conjugate (ADC), combined with the BCL2 inhibitor venetoclax in acute myeloid leukemia (AML). Evidence from preclinical studies suggests that venetoclax dampens the DNA damage response induced by this agent for a highly synergistic effect. This interview took place at the 65th ASH Annual Meeting and Exposition, held in San Diego, CA.
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