MGRS is a new classification of clonal disorders that cause kidney disease. Currently we know that this can be caused by a plasma cell clone, a B-cell clone, which mostly are LPL clones and CLL clones. The main importance of the concept of MGRS is that, in these diseases, clone-directed therapy is necessary for preservation of kidney function. However, unlike in multiple myeloma, extended prolonged therapy is generally not required...
MGRS is a new classification of clonal disorders that cause kidney disease. Currently we know that this can be caused by a plasma cell clone, a B-cell clone, which mostly are LPL clones and CLL clones. The main importance of the concept of MGRS is that, in these diseases, clone-directed therapy is necessary for preservation of kidney function. However, unlike in multiple myeloma, extended prolonged therapy is generally not required. Generally, time-limited therapy is sufficient to result in renal response and a prolonged remission.