Noopur Raje, MD, Massachusetts General Hospital, Boston, MA, discusses findings from a Phase II trial evaluating the efficacy of a combined regime of carfilzomib, lenalidomide, dexamethasone, and isatuximab (Isa-KRD) in transplant-eligible patients with newly diagnosed multiple myeloma (NCT04430894). So far, early data has shown an overall high response rate to this quadruplet regime as well as a high proportion of patients achieving measurable residual disease (MRD) negativity. Dr Raje also mentions that most patients decided to continue maintenance therapy over receiving stem cell transplantation. This interview took place at the 64th ASH Annual Meeting and Exposition congress in New Orleans, LA.
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