Stephen M. Ansell, MD, PhD, Mayo Clinic, Rochester, MN, reflects on the role of transplant in lymphoma, highlighting the increased prevalence of first-line CAR-T approaches versus autologous transplant (autoSCT) as well as the use of allogeneic transplant (alloSCT), which is associated with increased toxicity. This interview took place at the American Society of Clinical Oncology (ASCO) 2022 Annual Meeting in Chicago, IL.