Pieter Sonneveld, MD, PhD, Erasmus University, Rotterdam, The Netherlands, comments on the role of autologous stem cell transplantation (ASCT) in the treatment of patients with amyloidosis. Prof. Sonneveld describes how poor tolerability to intensive therapies is a major challenge to ASCT for these patients. Nevertheless, several studies have reported positive results for ASCT. In addition, Prof. Sonneveld describes how novel agents initially developed to treat myeloma have also demonstrated efficacy in amyloidosis. This interview took place at the 6th Congress on Controversies in Stem Cell Transplantation and Cellular Therapies (COSTEM), which took place virtually.