Prithviraj Bose, MD, The University of Texas MD Anderson Cancer, Houston, TX, discusses novel approaches to treating cytopenic myelofibrosis (MF). Dr Bose predominantly talks on the JAK2 inhibitor pacritinib, highlighting outcomes from the Phase III PERSIST-1 (NCT01773187) and PERSIST-2 (NCT02055781) trials. Dr Bose also talks on the ability of momelotinib, luspatercept, and pelabresib to ameliorate anemia. This interview took place during the ninth annual meeting of the Society of Hematologic Oncology (SOHO 2021) congress.