Enrique Ocio, MD, PhD, of Marqués de Valdecilla University Hospital, Santander, Spain, speaks on novel targets, therapies, and combinations for multiple myeloma, and comments on future directions for its treatment. In particular, Dr Ocio talks on the novel agents which have gained FDA approval such as selinexor, melflufen, and belantamab mafodotin, as well as discussing the role of combinatorial approaches. This interview took place during the 18th International Myeloma Workshop (IMW 2021) congress.