So, allo-CARs are being evaluated by different parties. There are allo-CARs targeting BCMA, and we have seen at last ASH that these allo-CARs are very promising in heavily pretreated patients with high activity and a manageable safety profile. There are also allo-CARs targeting stem of seven being investigated in clinical trials. And the big advantage of allo-CARs is potentially that they are directly available for patients that need treatment urgently and do not have the time to wait for the manufacturing of autologous CAR T-cells...
So, allo-CARs are being evaluated by different parties. There are allo-CARs targeting BCMA, and we have seen at last ASH that these allo-CARs are very promising in heavily pretreated patients with high activity and a manageable safety profile. There are also allo-CARs targeting stem of seven being investigated in clinical trials. And the big advantage of allo-CARs is potentially that they are directly available for patients that need treatment urgently and do not have the time to wait for the manufacturing of autologous CAR T-cells.
But the disadvantage of allo-CARs is that they are from a third party. So, from a healthy donor or, and that may lead to rapid rejection. So, you have to manipulate these allogeneic T-cells, for example by eradicating the T-cell receptor or by eradicating beta two microglobulin, to improve the persistence of these allo-CARs and also to prevent graft-versus-host disease. And I think in the next few conferences we will learn more about allo-CARs.
On the other hand, we also have now new manufacturing strategies that are much faster than the ones that we are using now. So, also these new manufacturing strategies where we can produce CAR T-cells in one week. So, this will also lead to a much shorter bench-to-end time, will hopefully be of benefit for patients that need treatment urgently.