Constantine Tam, MBBS, MD, FRACP, FRCPA from the University of Melbourne, Melbourne, Australia and fellow chronic lymphocytic leukemia (CLL) expert, Matthew Davids, MD from the Dana-Farber Cancer Institute, Boston, MA, discuss pursuing a career in CLL research as a young investigator. Prof. Tam and Dr Davids discuss their experiences as young investigators and provide advice to those considering a clinical or laboratory based role in CLL research. This discussion follows the Young Investigator Meeting, held during the International Workshop on Chronic Lymphocytic Leukemia (iwCLL) 2017 held in New York, NY.